In this respect, most infected people hardly notice this infection for a long time. ĭespite several pathological changes, most patients with clonorchiasis complain no or mild non-specific symptoms. It was reported that the secretory and excretory proteins are responsible for development of several pathological changes in the bile duct including cholangiocarcinoma and other complications.
Adult worms produce excretory and secretory proteins, sperms, and eggs at 3 to 4 weeks after infection. The metacercariae excyst in the duodenum, and the larvae migrate into the bile duct and grow up to adult worms. sinensis, results from ingestion of its metacercariae by consumption of raw or undercooked freshwater fish. Clonorchiasis, a disease caused by infection of C. Several hyperendemic foci are scattered in China and Korea.
Clonorchis sinensis is the most widespread parasitic fluke in East Asia.
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